Functional bacterial cellulose nanofibrils with silver nanoparticles and its antibacterial application
Aoqiong Zeng1, Ruijin Yang1, Yanjun Tong1
1State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu 214122, PR China; National Engineering Research Center for Functional Food, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu 214122, PR China.
International Journal of Biological Macromolecules
|February 22, 2023
Summary
This study introduces a green method to create silver nanoparticle-functionalized bacterial cellulose (BC) for wound healing. The new SABC/AgNPs material shows strong antimicrobial properties against common bacteria.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Microbiology
Background:
- Bacterial cellulose (BC) possesses excellent biocompatibility and mechanical strength, making it suitable for various applications.
- Silver nanoparticles (AgNPs) enhance BC's antimicrobial properties for wound healing, but their synthesis often involves toxic chemicals.
- Environmentally friendly methods for AgNP synthesis on BC are crucial for sustainable biomedical applications.
Purpose of the Study:
- To develop a novel, eco-friendly method for synthesizing silver nanoparticle-functionalized bacterial cellulose (AgNPs-BC).
- To investigate the potential of D-Saccharic acid potassium salt (SA)-grafted BC (SABC) as a scaffold for in situ AgNP synthesis.
- To evaluate the antimicrobial efficacy of the synthesized SABC/AgNPs composite for wound healing applications.
Main Methods:
- Fabrication of D-Saccharic acid potassium salt (SA)-grafted BC (SABC) via direct biosynthesis using Komagataeibacter xylinus.
- In situ synthesis of silver nanoparticles (AgNPs) on SABC nanofibers through an ion-exchange process followed by thermal reduction, avoiding chemical reducing agents.
- Characterization of SABC/AgNPs morphology and microstructure using field-emission scanning electron microscopy (FESEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS).
Main Results:
- A novel SABC/AgNPs composite material was successfully synthesized using a green, metabolically driven approach.
- Characterization confirmed the presence and uniform distribution of AgNPs (approx. 25.2 nm) on the SABC nanofiber surfaces.
- The SABC/AgNPs pellicles demonstrated significant antibacterial activity against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus.
Conclusions:
- This study presents a sustainable and efficient method for producing functionalized BC-based antimicrobial materials.
- The developed SABC/AgNPs composite exhibits potent antibacterial properties, highlighting its potential for advanced wound healing treatments.
- The findings offer a promising pathway for developing next-generation biomaterials with enhanced therapeutic functionalities.
