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Clinical features of asthma with connective tissue diseases

Keisuke Watanabe1, Nobuyuki Horita1, Yu Hara1

  • 1Department of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

The Clinical Respiratory Journal
|February 22, 2023
PubMed

Insights

Asthma in patients with connective tissue diseases (CTDs) is linked to reduced lung function and lower eosinophilic inflammation. This highlights distinct clinical features in asthma patients with co-occurring CTDs.

Area of Science:

  • Pulmonology
  • Rheumatology
  • Immunology

Background:

  • Clinical features of asthma co-occurring with connective tissue diseases (CTDs) are not well-defined.
  • Understanding these associations is crucial for comprehensive patient care.

Purpose of the Study:

  • To investigate the clinical characteristics of asthma in patients with co-existing CTDs.
  • To compare asthma patients with and without CTDs.

Main Methods:

  • Retrospective analysis of adult asthma patients from January 2010 to December 2019.
  • Comparison of clinical features between asthma patients with and without CTDs.

Main Results:

  • 7.4% of asthma patients had CTDs, most commonly rheumatoid arthritis (54.8%) and systemic lupus erythematosus (14.3%).
  • Asthma with CTDs showed a higher proportion of women (85.7% vs 56.5%) and more severe asthma (GINA step 4/5: 81.0% vs 62.0%).
  • Patients with asthma and CTDs had lower eosinophil ratios, lower total IgE levels, and significantly reduced lung function (FVC and FEV1).

Conclusions:

  • Asthma associated with CTDs is characterized by diminished lung function.
  • Asthma in CTD patients often presents as low-T2 inflammation type asthma.
Abstract

Keywords:
T2-low asthmaasthmaconnective tissue diseaseslung functionrheumatoid arthritis

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