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Related Concept Videos

Bone Disorders01:29

Bone Disorders

3.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.4K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.8K
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

23
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
23
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

3.5K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
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Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
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[Osteoporosis: diagnostics and treatment].

Ulla Stumpf1, Moritz Kraus1, Roland Ladurner2

  • 1Klinik für Orthopädie und Unfallchirurgie, Muskuloskelettales Universitätszentrum München (MUM), Klinikum der Universität München, LMU München, Marchioninistr. 15, 81377, München, Deutschland.

Orthopadie (Heidelberg, Germany)
|February 22, 2023
PubMed
Summary

Osteoporosis, a common bone disease, significantly impacts patient quality of life and survival. Early detection and consistent treatment are crucial for managing osteoporosis and maintaining patient independence.

Keywords:
Antiresorptive drugsDiagnosticsHyperparathyroidismOsteoanabolic treatmentSecondary osteoporosis

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Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
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Area of Science:

  • Orthopedics and Traumatology
  • Rheumatology
  • Gerontology

Context:

  • Osteoporosis is a prevalent global skeletal disorder with significant morbidity and mortality.
  • Established diagnostic and treatment guidelines (German/International S3) exist.
  • A notable disparity in osteoporosis diagnosis and management persists, particularly in Germany.

Purpose:

  • To emphasize early disease detection for osteoporosis.
  • To advocate for specific and consistent osteoporosis treatment strategies.
  • To improve long-term quality of life and independence for affected individuals.

Summary:

  • Osteoporosis diagnosis and treatment gaps hinder optimal patient outcomes.
  • The paper highlights the critical role of surgeons, orthopedic, and trauma specialists in managing manifest osteoporosis.
  • Consistent treatment approaches are essential for maintaining patient independence and quality of life.

Impact:

  • Enhancing early osteoporosis detection can improve patient prognosis.
  • Standardized and consistent treatment protocols are vital for managing osteoporosis effectively.
  • Addressing diagnostic and treatment gaps can reduce the substantial impact of osteoporosis on patients' lives and healthcare systems.