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Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

5.5K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.2K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.3K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.0K
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

3.3K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.3K
Production of Formed Elements01:34

Production of Formed Elements

1.5K
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
1.5K

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Related Experiment Video

Updated: Aug 9, 2025

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
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Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

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[Clonal Hematopoiesis and Solid Cancer].

Mamiko Sakata-Yanagimoto1, Kenichi Makishima, Yasuhito Suehara

  • 1Dept. of Hematology, Faculty of Medicine, University of Tsukuba.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|February 22, 2023
PubMed
Summary

Clonal hematopoiesis, the aging-related acquisition of somatic mutations in blood cells, is more frequent in solid tumor patients. Understanding this phenomenon is crucial for managing cancer patients.

Area of Science:

  • Hematology
  • Oncology
  • Genetics

Context:

  • Clonal hematopoiesis (CH) involves the proliferation of hematopoietic stem cells with somatic mutations due to aging.
  • CH is more prevalent in patients with solid tumors compared to healthy individuals.
  • Inflammatory cells with somatic mutations may infiltrate tumor tissues, potentially altering the tumor microenvironment.

Purpose:

  • To elucidate the general concept of clonal hematopoiesis.
  • To determine the frequency of CH in solid tumor patients.
  • To investigate the clinical course and tumor microenvironment impact of CH.

Summary:

  • This paper reviews clonal hematopoiesis (CH), a common aging-related phenomenon in hematopoietic stem cells.
  • It highlights the increased frequency of CH in solid tumor patients and its potential to influence the tumor microenvironment.

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Last Updated: Aug 9, 2025

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
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  • The study also examines the clinical characteristics and provides insights from mouse models.

    • Impact:

    • Provides essential knowledge for the clinical management of solid cancer patients.
    • Highlights the significance of incidental CH findings in gene panel testing.
    • Offers a foundation for further research into CH and its role in cancer progression.