[Clinical Features of Endocrine Disorders with Immune Checkpoint Inhibitor in Patients with Non-Small Cell Lung
Hironori Takagi1, Satoshi Muto, Mitsuro Fukuhara
1Dept. of Chest Surgery, Fukushima Medical University.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|February 22, 2023
Summary
Immune checkpoint inhibitors (ICIs) can cause endocrine disorders as immune-related adverse events (irAEs). Early diagnosis and multidisciplinary treatment are crucial for managing these irAEs in non-small cell lung cancer patients.
Area of Science:
- Oncology
- Endocrinology
- Immunology
Context:
- Immune checkpoint inhibitors (ICIs) are increasingly used for non-small cell lung cancer (NSCLC).
- Immune-related adverse events (irAEs) are known complications of ICIs.
- Endocrine disorders are a significant category of irAEs, presenting with challenging symptoms like fatigue, anorexia, and shock.
Purpose:
- To analyze the clinical characteristics of patients with non-small cell lung cancer who developed endocrine disorders as irAEs.
- To understand the presentation, management, and outcomes of these specific irAEs.
Summary:
- A retrospective study identified 7 NSCLC patients treated with ICIs who developed endocrine irAEs between 2016-2021.
- The most common endocrine irAEs were hypopituitarism (4 patients) and thyroid dysfunction (3 patients).
- Most patients (5/7) were able to resume ICI therapy after multidisciplinary management of irAEs.
Impact:
- Highlights the importance of recognizing endocrine disorders as potential irAEs in NSCLC patients receiving ICIs.
- Emphasizes the necessity of collaboration between oncology and endocrinology departments for timely diagnosis and effective treatment.
- Suggests that prompt management of endocrine irAEs can allow for continued ICI treatment in select patients.
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