Related Experiment Video For T-cells
Updated: Aug 9, 2025

07:29
Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
Published on: June 20, 2015
19.7K
Bicarbonate transport as regulator of antitumour immunity in pancreatic cancer
Emily J Kay1, Sara Zanivan1,2
1Cancer Research UK Beatson Institute, Glasgow, UK.
Molecular Oncology
|February 22, 2023
Abstract:
Bicarbonate transport is a pre-existing mechanism of pH regulation in pancreatic ductal cells. In a recent study, Cappellesso et al. demonstrated that pancreatic ductal adenocarcinoma metabolic rewiring creates an acidic environment, enhanced by bicarbonate import into cancer cells via SLC4A4. This acidity favours protumourigenic immunosuppression. Targeting SLC4A4 neutralises environmental pH and restores antitumour immunity, sensitising tumours to immune checkpoint blockade.

