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Pulmonary benign metastasizing leiomyoma: a case report
Emmanouil Panagiotou1, Ioannis Vamvakaris2, Nikolaos K Syrigos3
1Oncology Unit, Athens School of Medicine, Sotiria General Hospital, Athens. em_panagiotou@outlook.com.
Summary
Benign metastasizing leiomyoma is a rare condition where uterine leiomyoma cells spread to other organs. This case highlights a postmenopausal woman successfully treated with letrozole for lung metastases after a hysterectomy.
Area of Science:
- Reproductive medicine
- Oncology
- Pulmonary medicine
Background:
- Benign metastasizing leiomyoma (BML) is a rare condition characterized by the spread of benign uterine leiomyoma cells.
- BML typically affects women of reproductive age, often diagnosed years after hysterectomy for uterine fibroids.
Observation:
- A postmenopausal woman presented with dyspnea and a history of hysterectomy for leiomyoma.
- Chest CT revealed diffuse bilateral lung lesions.
- Open-lung biopsy confirmed leiomyoma cells in the lung tissue.
Findings:
- The patient received letrozole treatment for pulmonary leiomyoma.
- Clinical improvement was observed following letrozole therapy.
- No serious adverse events were reported during treatment.
Implications:
- This case suggests letrozole is a viable treatment option for benign metastasizing leiomyoma.
- It expands the understanding of BML presentation in postmenopausal women.
- Highlights the importance of considering BML in women with a history of uterine leiomyoma presenting with unexplained respiratory symptoms.
