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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Updated: Aug 9, 2025

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Targeted therapy for osteosarcoma: a review.

Shizhe Li^1,2, He Zhang¹, Jinxin Liu¹

¹Department of Bone and Soft Tissue Oncology, Shengjing Hospital Affiliated to China Medical University, Shenyang, 110022, Liaoning Province, China.

Journal of Cancer Research and Clinical Oncology

|February 22, 2023

Summary

This summary is machine-generated.

Molecular-targeted therapy shows promise for treating osteosarcoma, a challenging bone cancer in children and adolescents. While offering personalized treatment, drug resistance and side effects require further research for effective clinical application.

Keywords:

Molecular mechanism Osteosarcoma Tumour-targeted therapy

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Last Updated: Aug 9, 2025

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

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Published on: October 14, 2016

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

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Published on: March 18, 2014

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

Area of Science:

Oncology
Molecular Biology
Pharmacology

Background:

Osteosarcoma is a primary bone cancer common in children and adolescents.
Characterized by difficult treatment, recurrence, metastasis, and poor prognosis.
Current treatments (surgery, chemotherapy) are often ineffective for recurrent or resistant cases.

Purpose of the Study:

Review molecular mechanisms and targets of osteosarcoma-targeted therapy.
Summarize recent literature on targeted therapy's characteristics and clinical advantages.
Provide insights into future developments in osteosarcoma targeted therapy.

Main Methods:

Literature review of molecular mechanisms in osteosarcoma.
Analysis of identified molecular targets for therapy.
Evaluation of clinical applications and outcomes of targeted treatments.

Main Results:

Molecular-targeted therapy demonstrates potential for osteosarcoma treatment.
Identified targets and mechanisms offer new therapeutic strategies.
Targeted therapy may provide precise and personalized treatment options.

Conclusions:

Targeted therapy presents a promising approach for osteosarcoma.
Potential for precise and personalized treatment exists.
Drug resistance and adverse effects are limitations to its application.