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An Optic Nerve Crush Injury Murine Model to Study Retinal Ganglion Cell Survival

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Changes in integrins αv and α5 with Nogo-A in the rat retina after optic nerve injury

X-L Yin¹, J-P Zhang, J Ye

¹Department of Ophthalmology, Department of Medical Administration, The 305 Hospital of PLA, Beijing, China. yinxiaolei971221@163.com.

European Review for Medical and Pharmacological Sciences

|February 22, 2023

Abstract

Objective:

The purpose of this study was to investigate whether integrin levels are associated with axon regeneration after central nervous system (CNS) injury.

Materials And Methods:

By using immunohistochemistry, we performed a detailed investigation of the changes in and colocalization of integrins αv and α5, with Nogo-A in the retina after optic nerve injury.

Results:

We confirmed that integrins αv and α5 were expressed in the rat retina and colocalized with Nogo-A. After optic nerve transection, we found that integrin α5 levels increased over 7 days, but integrin αv levels remained unchanged, while Nogo-A levels increased.

Conclusions:

It seems that the inhibition of axonal regeneration by the Amino-Nogo-integrin signaling pathway may not occur via changes in integrin levels.

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