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Impact of chronic Helicobacter pylori infection on inflammatory markers and hematological parameters
1Department of Pediatrics, Department of Pediatric Gastroenterology and Hepatology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey. neslisaglam73@gmail.com.
Insights
Helicobacter pylori infection in children significantly alters inflammatory markers like neutrophils and platelet-to-lymphocyte ratio (PLR). This H. pylori link also correlates with lower ferritin and vitamin B12 levels, impacting pediatric health.
Area of Science:
- Pediatric Gastroenterology
- Infectious Diseases
- Hematology
Background:
- Helicobacter pylori (H. pylori) infection is a common cause of gastritis, particularly in children.
- Non-invasive diagnostic methods for H. pylori-induced gastritis are crucial for pediatric care.
- Chronic H. pylori infection can affect inflammatory and hematological profiles.
Purpose of the Study:
- To evaluate the impact of chronic H. pylori infection on inflammatory markers and hematological parameters in pediatric patients.
- To identify potential indicators for H. pylori infection in children with dyspeptic complaints.
Main Methods:
- A study involving 522 pediatric patients (2 months to 18 years) with chronic dyspeptic complaints.
- Analysis of complete blood count, ferritin, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR).
- Comparison of parameters between H. pylori positive and negative groups, and between groups with and without esophagitis.
Main Results:
- H. pylori was detected in 24.5% of patients; 54% had chronic gastritis.
- H. pylori positive patients showed significantly increased neutrophil and PLR values, and decreased NLR values.
- Significantly lower ferritin and vitamin B12 levels were observed in H. pylori positive children.
Conclusions:
- Neutrophil and PLR values are practical indicators of H. pylori infection's inflammatory phase in children.
- H. pylori infection is a significant factor contributing to iron deficiency and vitamin B12 deficiency anemia.
- Further large-scale studies are warranted to validate these findings for clinical application.
Objective:
Determining a non-invasive method for Helicobacter pylori (H. pylori) induced gastritis will be of great help especially in the field of pediatrics. In this study, we aimed to evaluate impact of chronic H. pylori infection on inflammatory markers and hematological parameters.
Patients And Methods:
522 patients aged between 2 months and 18 years, with chronic dyspeptic complaints who underwent gastroduodenoscopy were included. Complete blood count, ferritin, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) tests were performed. Platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR) values were calculated.
Results:
From 522 patients 54% had chronic gastritis and 28.6% had esophagitis, while 24.5% of their biopsy samples revealed H. pylori. The mean age of H. pylori positive patients was significantly higher (p<0.05). Females were in the majority in H. pylori positive and negative groups and in the group with esophagitis. The most common complaint in all groups was abdominal pain. In the H. pylori positive group, a significant increase in neutrophil and PLR values, a significant decrease in the NLR value were found. Ferritin and vitamin B12 values were significantly lower in the H. pylori positive group. No significant difference was found in the parameters we compared between the group with and without esophagitis, except for mean platelet volume (MPV). MPV values were significantly lower in the group with esophagitis.
Conclusions:
Neutrophil and PLR values are practical and easily obtainable parameters related to inflammatory phases of H. pylori infection. They may become useful parameters in the follow-up. H. pylori infection is one of the important causes that trigger iron deficiency and vitamin B12 deficiency anemia. Further large-scale randomized controlled studies are needed to confirm our results.
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