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Analysis of false positive PI-RADS 4 lesions: experience from a single nonacademic center using cognitive fusion
Bianca Carla Azevedo de Souza1,2,3, Marco Antonio Soares Novaes4, Maiara Ferreira de Souza5,6
1Federal University of Bahia/Hospital Universitário Professor Edgard Santos, R. Augusto Viana, s/n - Canela, Salvador, 40301-155, Brazil.
Background:
We evaluated pathological findings in targeted biopsies of PI-RADS4 and PI-RADS5 lesions, and clinical data that could predict those patients with benign findings.
Materials And Methods:
A retrospective study was conducted to summarize the experience from a single nonacademic center using cognitive fusion and a 1.5 or 3.0 Tesla scanner.
Results:
We found a false positive rate of 29 and 3.7% for any cancer in PI-RADS 4 and 5 lesions, respectively. Diverse histologic patterns were observed among target biopsies. At multivariate analysis, size ≤ 6 mm and previous negative biopsy were independent predictors of false positive PI-RADS4 lesions. The small number of false PI-RADS5 lesions precluded further analyses.
Conclusion:
Benign findings are common in PI-RADS4 lesions and most of them do not show obvious glandular or stromal hypercellularity as expected in hyperplastic nodules. Size ≤ 6 mm and previous negative biopsy predict a higher probability of false positive results in patients with PI-RADS 4 lesions.
