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Draft Genome Sequence of a Mixed-Serogroup W/Y Invasive Neisseria meningitidis Strain

Florian Mauffrey1, Nadia GaÏa1, Chiraz Chaabane1

  • 1Genomic Research Laboratory, Division of Infectious Diseases, Department of Medicine, University Hospitals and University of Geneva, Geneva, Switzerland.

Microbiology Resource Announcements
|February 22, 2023
PubMed

Insights

We sequenced the genome of Neisseria meningitidis strain GE-156 from a Swiss bacteremia patient. This rare W/Y serogroup strain is sequence type 11847, part of clonal complex 167.

Area of Science:

  • Microbiology
  • Genomics
  • Epidemiology

Background:

  • Neisseria meningitidis causes invasive meningococcal disease.
  • Serogroup W/Y strains are significant public health concerns.
  • Genomic surveillance is crucial for tracking bacterial evolution and spread.

Purpose of the Study:

  • To report the complete genome sequence of a Neisseria meningitidis strain isolated from a patient with bacteremia in Switzerland.
  • To characterize the strain's serogroup and sequence type using genomic data.

Main Methods:

  • Whole-genome sequencing of Neisseria meningitidis strain GE-156.
  • Bioinformatic analysis for serogroup determination and sequence typing.
  • Comparison with existing Neisseria meningitidis genomic databases.

Main Results:

  • The genome of Neisseria meningitidis strain GE-156 was successfully sequenced.
  • The strain was identified as a rare mixed serogroup W/Y.
  • Genomic analysis revealed the strain belongs to sequence type 11847, part of clonal complex 167.

Conclusions:

  • The genomic data provides valuable insights into the genetic makeup of this rare Neisseria meningitidis strain.
  • This characterization aids in understanding the epidemiology and potential transmission dynamics of W/Y meningococci in Switzerland.
  • Continued genomic surveillance is essential for monitoring meningococcal populations.

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