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Related Experiment Videos

Nicotinic acid-induced fulminant hepatic failure.

G L Clementz1, A W Holmes

  • 1Department of Family Practice, University of Illinois College of Medicine at Peoria 61656.

Journal of Clinical Gastroenterology
|October 1, 1987
PubMed
Summary

Nicotinic acid, used for high cholesterol, can cause severe liver injury. This case highlights the importance of monitoring for hepatotoxicity during treatment with nicotinic acid.

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Area of Science:

  • Hepatology
  • Clinical Pharmacology

Background:

  • Hypercholesterolemia is a common condition requiring treatment.
  • Nicotinic acid (niacin) is a lipid-lowering agent.
  • Hepatotoxicity is a known, though uncommon, side effect of nicotinic acid.

Observation:

  • A 46-year-old man developed liver injury after starting 3g daily nicotinic acid for hypercholesterolemia.
  • After a temporary cessation and re-initiation of therapy, the patient experienced fulminant hepatic failure.
  • Symptoms resolved rapidly upon discontinuation of nicotinic acid.

Findings:

  • The case suggests a direct causal link between nicotinic acid and drug-induced liver injury (DILI).
  • The rapid onset and severity of hepatic failure were notable.
  • This highlights the potential for significant hepatotoxicity even with short-term use.

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Implications:

  • Physicians and patients should be vigilant for signs of liver damage when using nicotinic acid.
  • Increased use of nicotinic acid for cholesterol management necessitates heightened awareness of its hepatotoxic potential.
  • Prompt recognition and cessation of the drug are crucial for managing nicotinic acid-induced liver injury.