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Updated: Aug 9, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Could an artificial intelligence approach to prior authorization be more human?
Leslie A Lenert1, Steven Lane2, Ramsey Wehbe3
1Biomedical Informatics Center, Medical University of South Carolina, Charleston, South Carolina, USA.
Prior authorization (PA) can be improved using artificial intelligence (AI). AI offers a more human-centric approach to healthcare decisions, reducing physician burnout and improving efficiency.
Area of Science:
- Health Informatics
- Artificial Intelligence in Healthcare
- Clinical Decision Support
Background:
- Prior authorization (PA) is a critical but burdensome process in healthcare.
- Current automated PA methods, like HL7 DaVinci, face limitations.
- PA contributes to physician burnout and can delay patient care.
Purpose of the Study:
- To propose an alternative, human-centric approach to PA using artificial intelligence (AI).
- To leverage existing electronic health data and AI for more efficient and just authorization decisions.
- To refine AI models with expert input and few-shot learning to mitigate bias.
Main Methods:
- Utilizing modern data access and exchange for electronic health records.
- Applying AI methods trained on expert panel judgments, including patient representatives.
- Employing few-shot learning techniques to minimize bias in AI models.
- Simulating human appropriateness assessments using AI.
Main Results:
- AI can efficiently simulate human appropriateness assessments from existing data.
- This approach has the potential to reduce administrative burdens and bottlenecks in PA.
- The proposed method aims to preserve the benefits of PA in limiting inappropriate care.
Conclusions:
- AI offers a promising alternative to current rule-based PA systems.
- A human-centric AI approach can create a more just and efficient healthcare system.
- Integrating AI with expert knowledge and patient perspectives can optimize PA processes.
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