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Updated: Aug 9, 2025

Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array
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Materials for Cell Surface Engineering.

Kolade Adebowale1,2, Rick Liao1,2, Vineeth Chandran Suja1,2

  • 1John A. Paulson School of Engineering and Applied Sciences, Harvard University, Allston, MA, 02134, USA.

Advanced Materials (Deerfield Beach, Fla.)
|February 22, 2023
PubMed
Summary
This summary is machine-generated.

Cell surface engineering enhances cell therapies by adding materials like nanoparticles. This improves therapeutic effects, protects cells, and aids targeted delivery for better treatment outcomes.

Keywords:
cell surface coatingscell therapycellular engineeringdrug deliverymicroparticlesnanomedicine

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Materials Science

Background:

  • Cell therapies offer new treatments for incurable diseases.
  • Cellular engineering is crucial for improving cell therapy efficacy.
  • Cell surface engineering is a key strategy in this field.

Purpose of the Study:

  • To review recent advances in cell surface engineering technologies.
  • To highlight how surface modifications enhance cell therapies.
  • To discuss the potential for clinical translation of these engineered cells.

Main Methods:

  • Decorating cell surfaces with nanoparticles, microparticles, and polymeric coatings.
  • Investigating the impact of surface modifications on carrier cells and therapeutic effects.
  • Summarizing findings from in vitro and in vivo preclinical studies.

Main Results:

  • Surface modifications protect carrier cells and reduce clearance.
  • Engineered cells show enhanced trafficking and antigen masking.
  • These modifications can deliver therapeutic agents and modulate inflammation.

Conclusions:

  • Cell surface engineering provides diverse advantages for cell therapy.
  • Surface-modified cells demonstrate promising therapeutic efficacy.
  • These advancements lay the groundwork for clinical translation and innovation.