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Published on: April 26, 2024
Protein-protein interaction and interference of carcinogenesis by supramolecular modifications
Oluwatosin A Saibu1, Sodiq O Hammed2, Oladapo O Oladipo3
1Department of Environmental Toxicology, Universitat Duisburg-Essen, NorthRhine-Westphalia, Germany.
Abstract:
Protein-protein interactions (PPIs) are essential in normal biological processes, but they can become disrupted or imbalanced in cancer. Various technological advancements have led to an increase in the number of PPI inhibitors, which target hubs in cancer cell's protein networks. However, it remains difficult to develop PPI inhibitors with desired potency and specificity. Supramolecular chemistry has only lately become recognized as a promising method to modify protein activities. In this review, we highlight recent advances in the use of supramolecular modification approaches in cancer therapy. We make special note of efforts to apply supramolecular modifications, such as molecular tweezers, to targeting the nuclear export signal (NES), which can be used to attenuate signaling processes in carcinogenesis. Finally, we discuss the strengths and weaknesses of using supramolecular approaches to targeting PPIs.
Insights
Supramolecular chemistry offers novel strategies for cancer therapy by targeting protein-protein interactions (PPIs). This approach, using tools like molecular tweezers, shows promise in developing more potent and specific PPI inhibitors for cancer treatment.
Area of Science:
- Biochemistry
- Molecular Biology
- Cancer Research
Background:
- Protein-protein interactions (PPIs) are crucial for biological processes but are often dysregulated in cancer.
- Developing potent and specific PPI inhibitors remains a significant challenge in cancer therapy.
Purpose of the Study:
- To review recent advances in supramolecular modification approaches for cancer therapy.
- To highlight the application of supramolecular chemistry in targeting cancer-related PPIs.
Main Methods:
- Review of current literature on supramolecular chemistry and PPI inhibition.
- Focus on supramolecular modifications like molecular tweezers targeting nuclear export signals (NES).
Main Results:
- Supramolecular chemistry presents a promising avenue for modulating protein activities and developing novel cancer therapeutics.
- Targeting NES with supramolecular tools offers a strategy to attenuate cancer-promoting signaling pathways.
Conclusions:
- Supramolecular approaches show potential for developing next-generation PPI inhibitors in cancer therapy.
- Further research is needed to fully explore the strengths and limitations of supramolecular strategies for PPI targeting.
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