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Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Inflammatory Response I: Vascular and Cellular01:30

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The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
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Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
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Necrosis01:16

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Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
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Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining
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Ferruginous bodies exert a strong proinflammatory effect.

Violetta Borelli1, Martina Zangari1, Annalisa Bernareggi1

  • 1Department of Life Science, University of Trieste, Trieste, Italy.

Journal of Toxicology and Environmental Health. Part A
|February 22, 2023
PubMed
Summary

Purified ferruginous-asbestos bodies (ABs) can stimulate inflammatory cells, potentially contributing to asbestos-related diseases. This study used magnetic properties to isolate ABs, preserving their structure for accurate analysis of their role in inflammation.

Keywords:
Ferruginous bodiesasbestos bodiesmast cellneutrophilsecretion process

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Area of Science:

  • Environmental Health Sciences
  • Toxicology
  • Pathology

Background:

  • Ferruginous-asbestos bodies (ABs) are linked to asbestos-related diseases.
  • Understanding the pathogenetic role of ABs is crucial for disease prevention and treatment.

Purpose of the Study:

  • To investigate whether purified ABs can stimulate inflammatory cells.
  • To explore a novel method for isolating ABs that preserves their native structure.

Main Methods:

  • Ferruginous-asbestos bodies (ABs) were isolated using magnetic properties, avoiding harsh chemical treatments.
  • The study assessed the effects of purified ABs on inflammatory cell secretion and degranulation.

Main Results:

  • Purified ABs induced the secretion of myeloperoxidase from human neutrophils.
  • Purified ABs stimulated degranulation in rat mast cells.
  • These findings suggest ABs can trigger secretory processes in inflammatory cells.

Conclusions:

  • Purified ABs play a role in the pathogenesis of asbestos-related diseases.
  • ABs enhance the pro-inflammatory activity initiated by asbestos fibers.
  • Magnetic isolation of ABs offers a method to study their biological effects without structural modification.