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The role of LncRNAs in tumor immunotherapy

Xuan Pan1, Chenchen Li2, Jifeng Feng3

  • 1Department of Medical Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, People's Republic of China. panxuan0214@163.com.

Cancer Cell International
|February 22, 2023
PubMed

Insights

Long non-coding RNAs (lncRNAs) are key regulators in cancer immunotherapy, influencing immune responses and treatment resistance. Understanding lncRNAs offers new avenues for cancer biomarkers and therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Cancer immunotherapy, particularly immune checkpoint inhibitors (ICIs), has revolutionized tumor treatment.
  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in cancer development and immune modulation.
  • Abnormal lncRNA expression is linked to tumor progression and resistance to immunotherapy.

Purpose of the Study:

  • To review the mechanisms by which lncRNAs regulate gene expression and immune checkpoint pathways.
  • To describe the critical functions of immune-related lncRNAs in cancer immunotherapy.
  • To highlight the potential of lncRNAs as biomarkers and therapeutic targets in cancer immunotherapy.

Main Methods:

  • Literature review and synthesis of existing research on lncRNAs and cancer immunotherapy.
  • Analysis of lncRNA regulatory mechanisms in gene expression.
  • Examination of lncRNA involvement in immune checkpoint pathways (CTLA-4/B7, PD-1/PD-L1).

Main Results:

  • lncRNAs play significant roles in modulating anti-tumor immunity and overcoming immunotherapy resistance.
  • Specific lncRNAs are involved in regulating key immune checkpoint pathways.
  • lncRNAs influence tumor immune microenvironment and patient responses to ICIs.

Conclusions:

  • lncRNAs are crucial regulators in cancer immunotherapy, impacting both immune response and therapeutic efficacy.
  • Further elucidation of lncRNA functions is essential for developing novel diagnostic biomarkers and targeted therapies.
  • Targeting lncRNAs holds promise for enhancing the effectiveness of current cancer immunotherapies.
Keywords:
CTLA-4LncRNAsPD-1PD-L1TIM-3Tumor immunotherapy

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