Related Experiment Video
Updated: Aug 9, 2025

Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure
Published on: January 18, 2021
Modified prolonged exposure therapy as Early Intervention after Rape (The EIR-study): study protocol for a
Tina Haugen1,2,3, Joar Øveraas Halvorsen4,5, Oddgeir Friborg6
1Department of Psychology, Norwegian University of Science and Technology (NTNU), NO-7491, Trondheim, Norway. tina.haugen@ntnu.no.
Modified prolonged exposure (mPE) therapy may prevent post-traumatic stress symptoms (PTSD) after rape. This trial assesses mPE's effectiveness in reducing PTSD in sexual assault survivors, guiding future clinical interventions.
Area of Science:
- Trauma and PTSD research
- Clinical psychology interventions
- Women's health after sexual assault
Background:
- Sexual assault and rape are leading causes of post-traumatic stress disorder (PTSD).
- Modified prolonged exposure (mPE) therapy shows promise in preventing PTSD after trauma.
- Early intervention in sexual assault survivors is crucial for mitigating long-term psychological effects.
Purpose of the Study:
- To evaluate the efficacy of modified prolonged exposure (mPE) therapy in preventing post-traumatic stress symptoms (PTSD) in recent rape survivors.
- To assess the impact of mPE on secondary outcomes including depression, sleep disturbances, and sexual dysfunction.
- To determine the feasibility and acceptance of mPE as an early intervention in sexual assault centers.
Main Methods:
- A multicenter randomized controlled trial involving patients within 72 hours of rape or attempted rape.
- Participants randomized to mPE plus treatment as usual (TAU) or TAU alone.
- Primary outcome: PTSD symptoms at 3 months post-trauma; secondary outcomes: depression, sleep, pelvic floor hyperactivity, sexual dysfunction.
Main Results:
- The study is designed to assess the primary outcome of PTSD symptom development at 3 months.
- Secondary outcomes will provide comprehensive data on the intervention's broader effects.
- An internal pilot trial will assess intervention acceptance and assessment feasibility for the first 22 subjects.
Conclusions:
- This research will inform clinical practice and guide future strategies for preventing PTSD after rape.
- Findings will identify specific patient groups who may benefit most from early mPE intervention.
- Results will contribute to revising existing treatment guidelines for sexual assault survivors.
Related Concept Videos
Post-traumatic Stress Disorder
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
Traumatic Memory
Interpersonal Psychotherapy
Behavior Therapy
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
Electroconvulsive Therapy
Autism Spectrum Disorder
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.

