Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Potentiation01:35

Long-term Potentiation

55.5K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
55.5K
Long-term Depression01:03

Long-term Depression

2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

It's not just the phase: Frequency-dependent tuning of neuronal firing.

PLoS biology·2026
Same author

Simulation Study of Enhancement-Mode <i>β</i>-Ga<sub>2</sub>O<sub>3</sub> MOSFETs on a Novel P-Ga<sub>2</sub>O<sub>3</sub>/AlN/SiC Substrate.

Micromachines·2026
Same author

Pre-stimulus alpha power modulates trial-by-trial variability in theta rhythmic multisensory entrainment strength and theta-induced memory effect.

Communications psychology·2026
Same author

LKNet: Enhancing rice canopy panicle counting accuracy with an optimized point-based framework.

Plant phenomics (Washington, D.C.)·2025
Same author

A Novel Design Strategy for Customized Polyetheretherketone Implants in Paranasal Augmentation Through Surgeon-Engineer Collaboration.

Aesthetic plastic surgery·2025
Same author

Beyond genotype: the influence of developmental stage on rice rhizospheric microbiome-metabolome networks.

BMC plant biology·2025

Related Experiment Video

Updated: Aug 9, 2025

TMS: Using the Theta-Burst Protocol to Explore Mechanism of Plasticity in Individuals with Fragile X Syndrome and Autism
10:58

TMS: Using the Theta-Burst Protocol to Explore Mechanism of Plasticity in Individuals with Fragile X Syndrome and Autism

Published on: December 28, 2010

17.0K

Interaction between Theta Phase and Spike Timing-Dependent Plasticity Simulates Theta-Induced Memory Effects.

Danying Wang1,2, George Parish2, Kimron L Shapiro2

  • 1School for Psychology and Neuroscience and Centre for Cognitive Neuroimaging, University of Glasgow, Glasgow G12 8QQ, United Kingdom Danying.Wang@glasgow.ac.uk Simon.Hanslmayr@glasgow.ac.uk.

Eneuro
|February 22, 2023
PubMed
Summary

Computational models reveal that spike timing-dependent plasticity (STDP) and theta phase-dependent learning are crucial for human episodic memory formation and function.

Keywords:
STDPepisodic memorytheta oscillations

More Related Videos

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
07:33

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

11.8K
Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
11:31

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex

Published on: February 25, 2022

2.4K

Related Experiment Videos

Last Updated: Aug 9, 2025

TMS: Using the Theta-Burst Protocol to Explore Mechanism of Plasticity in Individuals with Fragile X Syndrome and Autism
10:58

TMS: Using the Theta-Burst Protocol to Explore Mechanism of Plasticity in Individuals with Fragile X Syndrome and Autism

Published on: December 28, 2010

17.0K
Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
07:33

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

11.8K
Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
11:31

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex

Published on: February 25, 2022

2.4K

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Cognitive Science

Background:

  • Rodent studies link synaptic plasticity (potentiation/depression) to spike timing relative to hippocampal theta activity.
  • Spike-timing-dependent plasticity (STDP) and theta phase-dependent learning are key computational models for memory.
  • Direct evidence linking these mechanisms to human episodic memory is limited.

Purpose of the Study:

  • To investigate the direct link between STDP, theta phase-dependent plasticity, and human episodic memory using a computational model.
  • To determine if these circuit-level mechanisms can replicate findings in human episodic memory.

Main Methods:

  • Developed a computational model modulating long-term potentiation (LTP) and long-term depression (LTD) of STDP.
  • Incorporated opposing phases of a simulated theta rhythm to modulate plasticity.
  • Fitted model parameters to hippocampal cell culture data.
  • Simulated two inputs with 0° and asynchronous phase offsets to mimic human episodic memory findings.

Main Results:

  • A learning advantage was observed for in-phase theta-modulated inputs compared to out-of-phase conditions.
  • This learning advantage was specific to theta-modulated inputs.
  • Simulations demonstrated that both STDP and theta phase-dependent plasticity are necessary to replicate findings.

Conclusions:

  • Circuit-level mechanisms, specifically STDP and theta phase-dependent plasticity, play a significant role in human episodic memory.
  • These findings bridge the gap between cellular/slice preparation studies and human memory research.