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Related Concept Videos

Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

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Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
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Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
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Screening for PTSD and TBI in Veterans using Routine Clinical Laboratory Blood Tests.

Mu Xu1,2, Ziqiang Lin1,2, Carole E Siegel1,2,3,4

  • 1Center for Precision Medicine in Alcohol Use Disorder and PTSD, Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, USA.

Translational Psychiatry
|February 22, 2023
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Summary
This summary is machine-generated.

Objective blood tests could help diagnose post-traumatic stress disorder (PTSD) and traumatic brain injury (TBI). Routine Clinical Laboratory Improvement Amendments (CLIA) tests show potential for screening these conditions in veterans, aiding early detection.

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Area of Science:

  • Neuroscience
  • Clinical Diagnostics
  • Biomarker Discovery

Background:

  • Post-traumatic stress disorder (PTSD) and traumatic brain injury (TBI) share overlapping symptoms, complicating diagnosis.
  • Current diagnostic methods rely on subjective patient self-reports and clinical interviews, which can be unreliable.
  • Veterans exposed to warzones are at high risk for both PTSD and TBI, necessitating accurate and accessible screening tools.

Purpose of the Study:

  • To develop objective diagnostic screening tests for PTSD and TBI using readily available Clinical Laboratory Improvement Amendments (CLIA) blood tests.
  • To evaluate the efficacy of random forest (RF) models in differentiating between PTSD, TBI, and healthy controls using CLIA data.

Main Methods:

  • Collected CLIA blood test results from 475 male veterans with and without PTSD and TBI.
  • Utilized random forest (RF) methods and stepwise forward variable selection to build classification models.
  • Assessed model performance using AUC, accuracy, sensitivity, and specificity.

Main Results:

  • RF models demonstrated potential in differentiating PTSD and TBI from healthy controls, with AUCs ranging from 0.704 to 0.739.
  • Models successfully distinguished between PTSD and TBI cases, as well as comorbid PTSD/TBI from healthy controls.
  • Key discriminating CLIA features included markers of glucose metabolism and inflammation; comorbid conditions did not confound the models.

Conclusions:

  • Routine CLIA blood tests can serve as objective screening measures for PTSD and TBI.
  • These findings support the development of accessible, low-cost biomarker tests for primary care and specialty settings.
  • Objective blood tests could significantly improve the diagnostic process for PTSD and TBI in at-risk populations.