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Emerging roles of m6A RNA modification in cancer therapeutic resistance

Wei-Wei Liu1,2, Zhong-Yuan Zhang3, Fei Wang4

  • 1Department of Laboratory Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

Experimental Hematology & Oncology
|February 22, 2023
PubMed

Insights

N6-methyladenosine (m6A) RNA modification is a key epigenetic factor influencing cancer therapy resistance. Understanding m6A regulators offers potential strategies to overcome resistance and improve cancer treatment outcomes.

Area of Science:

  • Epigenetics
  • Molecular Biology
  • Oncology

Background:

  • Cancer therapies have advanced, but therapeutic resistance remains a significant challenge.
  • N6-methyladenosine (m6A) RNA modification is increasingly recognized as a critical factor in cancer therapeutic resistance.
  • m6A modification influences multiple RNA metabolic processes, including splicing, nuclear export, translation, and stability.

Purpose of the Study:

  • To review the regulatory mechanisms of m6A in various cancer therapies, including chemotherapy, targeted therapy, radiotherapy, and immunotherapy.
  • To discuss the clinical potential of targeting m6A modification to overcome therapeutic resistance.
  • To identify current research challenges and future prospects in the field of m6A and cancer therapy.

Main Methods:

  • Literature review focusing on m6A RNA modification and its role in cancer therapeutic resistance.
  • Analysis of the roles of m6A 'writers', 'erasers', and 'readers' in modulating resistance.
  • Discussion of clinical implications and future research directions.

Main Results:

  • m6A modification, regulated by writers, erasers, and readers, plays a crucial role in resistance to diverse cancer treatments.
  • m6A regulators are implicated in chemotherapy, targeted therapy, radiotherapy, and immunotherapy resistance.
  • Evidence suggests m6A modification can be a target to enhance cancer therapy efficacy.

Conclusions:

  • m6A RNA modification is a pivotal epigenetic mechanism influencing cancer therapeutic resistance.
  • Targeting m6A regulators presents a promising avenue for developing novel strategies to overcome treatment resistance.
  • Further research is needed to fully elucidate m6A's role and translate findings into clinical applications.
Keywords:
Cancer therapyChemoresistanceImmunotherapym6A

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