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Related Concept Videos

Typical Model Studies01:30

Typical Model Studies

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Fluid mechanics model studies often utilize scaled-down systems to predict fluid behavior in full-scale environments, such as river flows, dam spillways, and structures interacting with open surfaces. Maintaining Froude number similarity in river models is crucial, as it replicates surface flow features like wave patterns and velocities.
411
Design Example: Flow of Oil Through Circular Pipes01:25

Design Example: Flow of Oil Through Circular Pipes

165
Understanding fluid flow behavior through pipes is critical in fluid mechanics, especially in applications like oil transportation through pipelines. Hagen-Poiseuille's law provides an exact solution derived from the Navier-Stokes equations for steady, incompressible, and laminar flow within a circular pipe. Hagen-Poiseuille's law helps determine the necessary pressure drop across a pipeline section by determining parameters like pipe length, radius, oil viscosity, and the desired...
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Steady, Laminar Flow in Circular Tubes01:23

Steady, Laminar Flow in Circular Tubes

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Hagen-Poiseuille flow describes a viscous fluid's steady, incompressible flow through a cylindrical tube with a constant radius R. This flow profile is often applied to understand fluid transport in narrow channels, such as capillaries. It serves as a foundational example of laminar flow. In this model, cylindrical coordinates (r,θ,z) are used to describe the radial (r), angular (θ), and axial (z) dimensions within the tube. For Hagen-Poiseuille flow, the velocity profile is...
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Design Example: Creating a Hydraulic Model of a Dam Spillway01:21

Design Example: Creating a Hydraulic Model of a Dam Spillway

262
Scaled hydraulic models of dam spillways provide a practical way to replicate and study the intricate flow dynamics of these structures. Often built to a 1:15 ratio, these models allow for observing critical water behavior, such as velocity distribution, flow patterns, and energy dissipation.
262
Modeling and Similitude01:12

Modeling and Similitude

312
Scaled modeling is a fundamental technique in engineering, enabling the study of large and complex systems by creating smaller, manageable replicas that recreate critical characteristics of the original. In hydrology and civil infrastructure, for example, scaled models of dams help analyze water flow, turbulence, and pressure. This method allows for accurate predictions of real-world behavior within a controlled environment, significantly reducing the cost and time involved in full-scale...
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Study on Performance Simulation of Vascular-like Flow Channel Model Based on TPMS Structure.

Jianping Shi1,2, Fuyin Wei1, Bilal Chouraki1

  • 1School of Electrical and Automation Engineering, Nanjing Normal University, Nanjing 210046, China.

Biomimetics (Basel, Switzerland)
|February 22, 2023
PubMed
Summary

Optimizing 3D bioprinted tissues with vascular networks enhances cell viability. Simulations of 3D TPMS vascular models guided in vitro perfusion culture, improving nutrient delivery and waste removal for tissue engineering.

Keywords:
3D bioprintingTPMS structuresfluid-solid couplingvascular flow channels

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Area of Science:

  • Biomedical Engineering
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • 3D bioprinted tissues offer alternatives to animal models in drug testing and clinical trials.
  • Ensuring nutrient and oxygen supply to internal cells in biomimetic tissues is critical for viability.
  • Vascular flow channels are essential for nutrient diffusion, cell growth, and waste removal in engineered tissues.

Purpose of the Study:

  • To develop and simulate a 3D TPMS vascular flow channel network model.
  • To analyze the impact of perfusion pressure on blood flow rate and channel wall pressure.
  • To optimize in vitro perfusion culture parameters for improved biomimetic tissue structures.

Main Methods:

  • Development of a 3D Triply Periodic Minimal Surface (TPMS) vascular flow channel network model.
  • Computational simulation to analyze fluid dynamics under varying perfusion pressures.
  • Optimization of perfusion culture parameters based on simulation results.

Main Results:

  • Simulation revealed the relationship between perfusion pressure, blood flow rate, and channel wall pressure.
  • Identified optimal perfusion pressure ranges to ensure adequate fluid distribution.
  • Demonstrated the potential to avoid perfusion failure and cell necrosis through parameter optimization.

Conclusions:

  • The developed 3D TPMS model and simulations aid in optimizing vascularized tissue engineering.
  • Proper control of perfusion pressure is crucial for maintaining cell viability and tissue function.
  • This research advances in vitro culture techniques for developing functional biomimetic tissues.