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Decoding the bidirectional relationship between gut microbiota and COVID-19.

Tanya Ralli1, Zoya Saifi1, Anjali Rathee2

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Summary
This summary is machine-generated.

COVID-19 (coronavirus disease 2019) impacts the gut microbiome, increasing susceptibility to infection. Modulating the gut microbiome with probiotics or prebiotics may improve COVID-19 outcomes.

Keywords:
ACE2COVID-19CoronavirusGut lung axisGut microbiome

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Area of Science:

  • Microbiology
  • Immunology
  • Virology

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, primarily affects the respiratory system.
  • Gastrointestinal symptoms and viral RNA in stool suggest gut involvement.
  • Emerging evidence indicates a bidirectional relationship between the gut microbiome and lung health in COVID-19.

Purpose of the Study:

  • To explore the mechanisms by which gut dysbiosis influences COVID-19 susceptibility.
  • To review the role of the gut-lung axis in COVID-19 pathogenesis.

Main Methods:

  • Literature review of studies on COVID-19 and the gut microbiome.
  • Analysis of the gut-lung axis in relation to SARS-CoV-2 infection.

Main Results:

  • Gut dysbiosis is linked to increased susceptibility to COVID-19.
  • SARS-CoV-2 infection can lead to alterations in the intestinal microbial composition.
  • The gut microbiome plays a significant role in COVID-19 disease progression.

Conclusions:

  • Understanding the gut-lung axis mechanisms is crucial for managing COVID-19.
  • Therapeutic strategies targeting the gut microbiome, such as prebiotics and probiotics, show promise.
  • Further clinical trials are needed to validate fecal microbiota transplantation for COVID-19 treatment.