Re-interpreting tumour behaviour and the tumour microenvironment as normal responses to tissue disorganisation
1Department of Pathology, University of Cambridge, Cambridge, UK.
Abstract:
Much of tumour cell biology and the tumour microenvironment may be normal wound-healing responses as a consequence of the disruption of tissue structure. This is why tumours resemble wounds, and many features of the tumour microenvironment, such as the epithelial-mesenchymal transition, cancer-associated fibroblasts, and inflammatory infiltrates, may largely be normal responses to abnormal tissue structure, not an exploitation of wound-healing biology. © 2023 The Author. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
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