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Updated: Aug 9, 2025

Biofunctionalization of Magnetic Nanomaterials

Biofunctionalization of Magnetic Nanomaterials

Published on: July 16, 2020

BIOMAGNETISM OF DRUG-SENSITIVE AND DRUG-RESISTANT MALIGNANT TUMORS AFTER INJECTION OF FERROMAGNETIC NANOCOMPOSITE.

I N Todor¹, N Yu Lukianova¹, M A Primin²

¹R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv 03022, Ukraine.

Experimental Oncology

|February 22, 2023

Summary

Magnetic signals can help visualize chemotherapy-resistant tumors. Using Ferroplat nanoparticles with SQUID-magnetometry significantly enhanced these signals, offering a promising diagnostic approach.

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Area of Science:

Biophysics
Biomagnetism
Nanotechnology

Background:

Magnetic signals from organisms are vital biophysical indicators.
Studying these signals aids in visualizing tumor progression and developing AI for chemotherapy-resistant cancers.

Purpose of the Study:

To measure magnetic signals from rat tumors sensitive and resistant to chemotherapy.
To evaluate the accumulation of the iron-containing nanocomposite Ferroplat in these tumors.

Main Methods:

Utilized Superconductive Quantum Interference Device (SQUID)-magnetometry for non-contact magnetic signal measurement.
Studied Doxorubicin-resistant and sensitive Walker-256 carcinosarcoma and cisplatin-resistant and sensitive Guerin's carcinoma in Wistar rats.
Administered Ferroplat intravenously and assessed biomagnetism after one hour.

Main Results:

Doxorubicin-resistant tumors exhibited significantly higher magnetic signals than sensitive ones.
Ferroplat administration increased biomagnetism by over tenfold, particularly in resistant tumors.
Magnetic signals from the liver and heart remained within background noise levels.

Conclusions:

SQUID-magnetometry combined with Ferroplat nanoparticles shows promise for visualizing malignant neoplasms.
This approach is effective for differentiating tumors based on their sensitivity to chemotherapy.