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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
A dual-amplified ROS-responsive nanosystem with self-accelerating drug release for synergistic chemotherapy
Jun Li1, Qingyu Zong2, Zhongyi Zhao3
1School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, P. R. China. yuanyy@scut.edu.cn.
Abstract:
In this work, we have developed a tumor-specific self-accelerating prodrug activation nanosystem consisting of self-amplifying degradable polyprodrug PEG-TA-CA-DOX and encapsulated fluorescent prodrug BCyNH2, equipped with a reactive oxygen species dual-cycle amplification effect. Furthermore, activated CyNH2 is a therapeutic agent with potential to synergistically improve chemotherapy.
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