Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Renal Corpuscle01:20

Renal Corpuscle

3.0K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
3.0K
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

52
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
52
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

66
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
66
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

49
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
49
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

46
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
46
Imaging Studies I: Kidney, Ureter, and Bladder Studies01:28

Imaging Studies I: Kidney, Ureter, and Bladder Studies

31
Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
31

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tirzepatide-associated interstitial kidney injury.

JCEM case reports·2026
Same author

Comparative 3-Year Allograft Outcomes for Recipients of Kidneys From SARS-CoV-2 NAT-Positive Donors.

Transplant infectious disease : an official journal of the Transplantation Society·2026
Same author

Mitochondrial DNA Analysis Should Be Considered in the Genetic Assessment of Focal Segmental Glomerulosclerosis or Unexplained Chronic Kidney Disease: A Case Report.

Kidney medicine·2026
Same author

Interactive visualization of kidney micro-compartmental segmentations and associated pathomics on whole slide images.

ArXiv·2025
Same author

Cellular and Spatial Drivers of Unresolved Injury and Functional Decline in the Human Kidney.

bioRxiv : the preprint server for biology·2025
Same author

The Pathology of Tubulointerstitial Kidney Disease: A Clinicopathologic Approach to Narrowing the Differential Diagnosis.

Advances in kidney disease and health·2025

Related Experiment Video

Updated: Aug 9, 2025

Optical Clearing and Imaging of Immunolabeled Kidney Tissue
06:18

Optical Clearing and Imaging of Immunolabeled Kidney Tissue

Published on: July 22, 2019

10.6K

Complement detection in kidney biopsies - utility and challenges.

Kristen Tomaszewski1, Leal Herlitz

  • 1Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio, USA.

Current Opinion in Nephrology and Hypertension
|February 22, 2023
PubMed
Summary

Complement staining in kidney biopsies aids in prognosis and disease activity assessment. Expanded panels are crucial for identifying patients who could benefit from targeted complement therapies.

More Related Videos

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.0K
Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis
09:16

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis

Published on: June 18, 2020

6.9K

Related Experiment Videos

Last Updated: Aug 9, 2025

Optical Clearing and Imaging of Immunolabeled Kidney Tissue
06:18

Optical Clearing and Imaging of Immunolabeled Kidney Tissue

Published on: July 22, 2019

10.6K
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.0K
Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis
09:16

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis

Published on: June 18, 2020

6.9K

Area of Science:

  • Nephrology
  • Immunology
  • Pathology

Background:

  • The complement cascade plays a critical role in kidney diseases and transplant rejection.
  • Current staining methods for complement components in kidney biopsies provide valuable insights but are often insufficient for comprehensive assessment.

Conclusions:

  • Complement staining in kidney biopsies is vital for understanding disease mechanisms.
  • Comprehensive complement analysis can guide therapeutic decisions, particularly for complement-targeted treatments.
  • Advancements in staining panels and molecular diagnostics enhance the ability to diagnose and manage kidney diseases and transplant complications.