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Updated: Aug 9, 2025

Optical Clearing and Imaging of Immunolabeled Kidney Tissue
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Published on: July 22, 2019

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Complement detection in kidney biopsies - utility and challenges

Kristen Tomaszewski1, Leal Herlitz

  • 1Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio, USA.

Current Opinion in Nephrology and Hypertension
|February 22, 2023
PubMed

Insights

Complement staining in kidney biopsies aids in prognosis and disease activity assessment. Expanded panels are crucial for identifying patients who could benefit from targeted complement therapies.

Area of Science:

  • Nephrology
  • Immunology
  • Pathology

Background:

  • The complement cascade plays a critical role in kidney diseases and transplant rejection.
  • Current staining methods for complement components in kidney biopsies provide valuable insights but are often insufficient for comprehensive assessment.

Conclusions:

  • Complement staining in kidney biopsies is vital for understanding disease mechanisms.
  • Comprehensive complement analysis can guide therapeutic decisions, particularly for complement-targeted treatments.
  • Advancements in staining panels and molecular diagnostics enhance the ability to diagnose and manage kidney diseases and transplant complications.
Abstract

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