Related Experiment Video
Updated: Aug 9, 2025
06:39
Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
Published on: August 19, 2020
5.7K
Collapsing glomerulopathy: unraveling varied pathogeneses
Kelly D Smith1, Shreeram Akilesh1,2
1Department of Laboratory Medicine and Pathology, University of Washington.
Current Opinion in Nephrology and Hypertension
|February 22, 2023
Summary
Collapsing glomerulopathy, a severe kidney disease, involves podocyte and glomerular endothelial cell injury. Emerging technologies analyze patient biopsies to understand its diverse mechanisms and improve diagnosis.
Area of Science:
- Nephrology
- Pathology
- Genetics
Background:
- Collapsing glomerulopathy is a variant of focal and segmental glomerulosclerosis (FSGS).
- Clinical presentation includes nephrotic syndrome and rapid kidney function decline.
- Numerous genetic and clinical conditions are linked to collapsing glomerulopathy.
Approach:
- Review of animal models and patient studies.
- Focus on podocyte injury mechanisms.
- Exploration of glomerular endothelial cell involvement and signaling pathways.
- Utilizing emerging technologies for molecular pathway analysis in patient biopsies.
Key Points:
- Podocyte injury is a primary focus, but glomerular endothelium injury also contributes.
- Interruption of the podocyte-glomerular endothelial cell signaling axis is implicated.
- Diverse molecular pathways can precipitate collapsing glomerulopathy.
- New technologies allow direct analysis of patient biopsies.
Conclusions:
- Collapsing glomerulopathy research has yielded significant insights into disease mechanisms.
- Intra-patient and inter-patient variability in mechanisms can be profiled.
- Advanced analysis of patient biopsies will enhance diagnosis and classification.
More Related Videos
Related Concept Videos
01:24Nephrotic Syndrome I : Introduction
15
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
15
01:29Acute Kidney Injury II: Pathophysiology
41
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
41
01:20Renal Corpuscle
3.0K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
3.0K
01:10Nephrons
3.2K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
3.2K
01:25Glaucoma: Overview
670
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
670
01:25Chronic Kidney Disease I: Introduction
52
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
52