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Left atrial strain assessment using cardiac computed tomography in patients with hypertrophic cardiomyopathy

Takaaki Hosokawa1, Hiroshi Kawakami2, Yuki Tanabe3

  • 1Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.

Japanese Journal of Radiology
|February 22, 2023
PubMed

Insights

Cardiac computed tomography (CT)-derived left atrial (LA) strain is a feasible method for assessing LA function in hypertrophic cardiomyopathy (HCM) patients. This technique offers reproducible quantitative analysis of LA strain parameters, aiding in HCM evaluation.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Hypertrophic cardiomyopathy (HCM) is a genetic heart disease characterized by left ventricular hypertrophy.
  • Left atrial (LA) function is a crucial indicator of cardiovascular health and can be affected in HCM.
  • Assessing LA function quantitatively can improve understanding and management of HCM.

Purpose of the Study:

  • To evaluate left atrial (LA) function in patients with hypertrophic cardiomyopathy (HCM) using cardiac computed tomography (CT)-derived LA strain.
  • To assess the feasibility and reproducibility of CT-derived LA strain for quantitative analysis in HCM.

Main Methods:

  • Retrospective analysis of 34 HCM patients and 31 non-HCM controls who underwent cardiac CT.
  • Semi-automated analysis of CT-derived LA strain (reservoir [LASr], conduit [LASc], and booster pump strain [LASp]) from ECG-gated CT images.
  • Measurement of left atrial volume index (LAVI) and left ventricular longitudinal strain (LVLS) to correlate with CT-derived LA strain.

Main Results:

  • CT-derived LA strain parameters (LASr, LASc, LASp) were significantly lower in HCM patients compared to non-HCM controls (p < 0.001 for all).
  • CT-derived LA strain showed significant correlations with LAVI (r = -0.35 to -0.70) and LVLS (r = -0.42 to -0.67).
  • High reproducibility was observed for CT-derived LA strain measurements (inter-observer coefficients 0.89–0.94).

Conclusions:

  • CT-derived LA strain is a feasible and reproducible method for quantitative assessment of left atrial function in patients with HCM.
  • This technique provides valuable insights into LA dysfunction associated with HCM.
  • CT-derived LA strain can be a useful tool in the comprehensive evaluation of HCM.
Abstract

Keywords:
Cardiac computed tomographyHypertrophic cardiomyopathyLeft atrial strain

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