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Impact of Crisaborole on Sleep Outcomes in Pediatric Patients with Mild-to-Moderate Atopic Dermatitis

Joseph Fowler1, Jeffrey Sugarman2, Lawrence Sher3

  • 1Dermatology Specialists Research LLC and University of Louisville School of Medicine, Louisville, KY, USA.

Dermatology and Therapy
|February 22, 2023
PubMed

Insights

Crisaborole ointment significantly improved sleep for children with atopic dermatitis (AD) and their families. Treatment reduced sleep disruption in pediatric patients and affected households.

Area of Science:

  • Dermatology
  • Pediatrics
  • Sleep Medicine

Background:

  • Atopic dermatitis (AD) significantly impacts sleep quality in pediatric patients and their families.
  • Evaluating the effect of topical treatments on non-dermatological outcomes like sleep is crucial for comprehensive patient care.

Purpose of the Study:

  • To assess the impact of crisaborole ointment on sleep outcomes in pediatric patients with mild-to-moderate atopic dermatitis.
  • To evaluate the effect of crisaborole treatment on the sleep of families with children diagnosed with atopic dermatitis.

Main Methods:

  • Analysis of data from three clinical trials (CORE 1, CORE 2, CARE 1) involving pediatric patients with atopic dermatitis.
  • Patients aged 2 to <16 years (CORE 1 & 2) and 3 months to <2 years (CARE 1) received crisaborole ointment 2% or vehicle twice daily for 28 days.
  • Sleep outcomes were measured using validated questionnaires including the Children's Dermatology Life Quality Index, Dermatitis Family Impact, and Patient-Oriented Eczema Measure.

Main Results:

  • Crisaborole treatment resulted in a significantly lower proportion of patients reporting sleep disruption compared to vehicle treatment (48.5% vs 57.7%, p=0.001).
  • A significantly lower proportion of families reported sleep affected by their child's AD in the crisaborole group (35.8% vs 43.1%, p=0.02).
  • In the CARE 1 study, crisaborole treatment led to a 32.1% decrease in disturbed sleep nights from baseline in pediatric patients.

Conclusions:

  • Crisaborole ointment demonstrates efficacy in improving sleep outcomes for pediatric patients suffering from mild-to-moderate atopic dermatitis.
  • The findings suggest that crisaborole treatment positively impacts the sleep quality of both affected children and their families.
Abstract

Keywords:
Atopic dermatitisCrisaborolePediatricsSleep

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