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Retraction

    Journal of Cellular Physiology
    |February 22, 2023
    PubMed

    Insights

    This study on thyroid cancer cell migration and invasion has been retracted due to unintentional research errors and data duplication. The findings are now considered invalid.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Genetics

    Context:

    • The original study investigated the role of long noncoding RNA LINC00313 in thyroid cancer.
    • It explored the potential of LINC00313 as an inhibitor of epithelial-mesenchymal transition, invasion, and migration.
    • The research focused on the mechanism involving the methylation of ALX4.

    Purpose:

    • To examine the inhibitory effect of downregulated long noncoding RNA LINC00313 on thyroid cancer cell progression.
    • To elucidate the molecular mechanism by which LINC00313 affects epithelial-mesenchymal transition, invasion, and migration.
    • To assess the role of ALX4 methylation in this process.

    Summary:

    • The article "Downregulated long noncoding RNA LINC00313 inhibits the epithelial-mesenchymal transition, invasion, and migration of thyroid cancer cells through inhibiting the methylation of ALX4" has been retracted.
    • Retraction was based on unintentional errors in the research process and unverified experimental results.
    • An investigation revealed data duplications and image inconsistencies, invalidating the study's conclusions.

    Impact:

    • The retraction invalidates findings related to LINC00313's role in inhibiting thyroid cancer cell epithelial-mesenchymal transition, invasion, and migration.
    • This impacts the understanding of potential therapeutic targets and mechanisms in thyroid cancer.
    • The scientific community must disregard the conclusions presented in the original publication.

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