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Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
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Long-read sequencing identifies novel structural variations in colorectal cancer

Luming Xu1,2, Xingyue Wang1,2, Xiaohuan Lu2,3

  • 1Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Plos Genetics
|February 22, 2023
PubMed
Summary

Long-read sequencing identified over 5000 novel structural variations (SVs) in colorectal cancer (CRC), revealing gene alterations that drive cancer progression and metastasis. This genomic approach offers potential for precise CRC diagnosis and personalized treatments.

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