A computational framework for the multiphysics simulation of microbubble-mediated sonothrombolysis using a
Zhi Q Tan1, Ean H Ooi2, Yeong S Chiew1
1Mechanical Engineering Discipline, School of Engineering, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor, Malaysia.
This study introduces a computational model for sonothrombolysis, revealing ultrasound pressure as the key factor influencing clot lysis. Optimized parameters, like microbubble size and concentration, enhance clot dissolution for potential clinical use.
Area of Science:
- Biomedical Engineering
- Acoustic Physics
- Computational Fluid Dynamics
Background:
- Sonothrombolysis uses ultrasound and microbubbles to break down blood clots.
- Optimal parameters for ultrasound and microbubbles are not well understood.
- Computational models are needed to simulate this complex interaction.
Purpose of the Study:
- To develop and validate a computational framework for simulating microbubble-mediated sonothrombolysis.
- To investigate the influence of ultrasound and microbubble parameters on clot lysis.
- To provide insights for optimizing sonothrombolysis for clinical applications.
Main Methods:
- Developed a computational framework coupling bubble dynamics with acoustic propagation.
- Simulated sonothrombolysis using a forward-viewing transducer.
- Investigated effects of ultrasound pressure, frequency, microbubble radius, and concentration.
Main Results:
- Ultrasound pressure is the most dominant parameter affecting bubble dynamics and clot displacement.
- Smaller microbubbles enhance acoustic radiation force (ARF) at higher pressures.
- Increased microbubble concentration boosts ARF; frequency effects depend on pressure.
Conclusions:
- The computational framework provides crucial insights into sonothrombolysis mechanisms.
- Ultrasound pressure, microbubble size, and concentration are key factors for effective clot lysis.
- Findings support the advancement of sonothrombolysis towards clinical implementation.
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