The Causality between Diabetes and Venous Thromboembolism: A Bidirectional Two-Sample Mendelian Randomization Study.
Song Hu1, Jiang-Shan Tan1, Meng-Jin Hu2
1Key Laboratory of Pulmonary Vascular Medicine, State Key Laboratory of Cardiovascular Disease, Center for Respiratory and Pulmonary Vascular Diseases, Department of Cardiology, National Clinical Research Center of Cardiovascular Diseases, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Thrombosis and Haemostasis
|February 22, 2023
Summary
This study found no causal link between type 1 or type 2 diabetes and venous thromboembolism (VTE). These findings challenge previous observational studies and offer new insights into the relationship between diabetes and VTE.
Area of Science:
- Cardiovascular epidemiology
- Metabolic disorders
- Genetic epidemiology
Background:
- Observational studies suggest diabetes is a risk factor for venous thromboembolism (VTE).
- Conflicting findings exist regarding the association between diabetes and VTE.
- This study investigates the causal relationship between type 1 and type 2 diabetes and VTE, including deep vein thrombosis (DVT) and pulmonary embolism (PE).
Purpose of the Study:
- To determine the causal association between type 1 diabetes and VTE.
- To determine the causal association between type 2 diabetes and VTE.
- To investigate the potential causal effect of VTE on diabetes development.
Main Methods:
- Utilized a bidirectional two-sample Mendelian randomization (MR) analysis.
- Employed summary-level data from large genome-wide association studies in European populations.
- Applied inverse variance weighting and multiple sensitivity analyses (weighted median, weighted mode, MR-Egger) to ensure result robustness.
Main Results:
- No significant causal effect of type 1 diabetes on VTE, DVT, or PE was observed.
- No significant causal effect of type 2 diabetes on VTE, DVT, or PE was identified.
- No significant causal effect of VTE on type 1 or type 2 diabetes was detected.
Conclusions:
- This Mendelian randomization study found no evidence of a causal association between type 1 or type 2 diabetes and VTE.
- The findings contradict previous observational studies that suggested a positive association.
- This research contributes to understanding the complex interplay between diabetes and VTE pathogenesis.
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