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OPUS-Mut: Studying the Effect of Protein Mutation through Side-Chain Modeling

Gang Xu1,2,3, Qinghua Wang4, Jianpeng Ma1,2,3

  • 1Multiscale Research Institute of Complex Systems, Fudan University, Shanghai 200433, China.

Journal of Chemical Theory and Computation
|February 22, 2023
PubMed
Summary

We developed OPUS-Mut, a computational method for predicting protein mutation effects by accurately modeling side-chain changes. This tool outperforms existing methods and aids in identifying harmful mutations for protein design.

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