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Peripheral neuropathy in mitochondrial disease

Rita Horvath1, Jessica Medina2, Mary M Reilly3

  • 1Department of Clinical Neurosciences, University of Cambridge, John van Geest Centre for Brain Repair, Cambridge, United Kingdom.

Handbook of Clinical Neurology
|February 22, 2023
PubMed
Summary

Mitochondrial dysfunction and genetic mutations disrupt neuron health, leading to peripheral neuropathies. Understanding these genetic causes and clinical signs is key for diagnosis and treatment.

Keywords:
Axonal transportCharcot–Marie–Tooth diseaseMitochondrial DNAMitochondrial fusion/fissionNuclear mitochondrial genesRespiratory chain enzymes

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