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Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
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Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding

Published on: June 9, 2017

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Advances in the molecular level understanding of G-protein coupled receptor

Adhiraj Roy1

  • 1Amity Institute of Molecular Medicine & Stem Cell Research, Amity University, Noida, Uttar Pradesh, India.

Progress in Molecular Biology and Translational Science
|February 22, 2023
PubMed

Insights

G-protein coupled receptors (GPCRs) are key cell signaling proteins. Research highlights their role in diseases and their potential as drug targets, with many therapies in development.

Area of Science:

  • Biochemistry and Molecular Biology
  • Cellular Signaling
  • Pharmacology

Background:

  • G-protein coupled receptors (GPCRs) are the largest family of cell surface receptors.
  • They mediate cellular responses to diverse extracellular signals like hormones and chemokines.
  • Dysregulation of GPCRs is implicated in major human diseases.

Purpose of the Study:

  • To provide an updated overview of G-protein coupled receptor (GPCR) research.
  • To emphasize the significance of GPCRs as therapeutic targets.
  • To highlight current drug development efforts targeting GPCRs.

Main Methods:

  • Literature review of current GPCR research.
  • Analysis of GPCR involvement in human diseases.
  • Survey of approved and investigational drugs targeting GPCRs.

Main Results:

  • GPCRs play critical roles in numerous cellular and physiological processes.
  • Aberrant GPCR expression and genetic mutations are linked to cancer and cardiovascular diseases.
  • A significant number of GPCR-targeting drugs are available or in clinical trials.

Conclusions:

  • G-protein coupled receptors (GPCRs) are vital for cell communication and function.
  • GPCRs represent a highly promising area for therapeutic intervention.
  • Continued research into GPCRs is essential for developing novel treatments for various diseases.
Keywords:
ArrestinG-protein coupled receptorG-protein coupled receptor kinasePathologySmall molecule inhibitors

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