Related Experiment Video

Updated: Aug 9, 2025

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

52.6K

Liver and Biliary Tract Disease in Patients with Coronavirus disease-2019 Infection

Sirina Ekpanyapong1, K Rajender Reddy2

  • 1Division of Gastroenterology and Hepatology, Department of Medicine, Huachiew General Hospital, 665 Bumroongmueang Road, Khlong Mahanak, Bangkok 10100, Thailand; Division of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania, 2 Dulles, Liver Transplant Office, HUP3400 Spruce Street, Philadelphia, PA 19104, USA.

Gastroenterology Clinics of North America
|February 22, 2023
PubMed

Insights

Patients with chronic liver disease, including transplant recipients, should get vaccinated against COVID-19. Vaccination reduces infection, hospitalization, and death from coronavirus disease 2019.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Immunology

Background:

  • Coronavirus disease 2019 (COVID-19) is a global pandemic.
  • Hepatic abnormalities occur in up to 50% of COVID-19 patients, potentially linked to disease severity.
  • The precise mechanisms of liver injury in COVID-19 are multifactorial.

Purpose of the Study:

  • To summarize current guidelines for managing chronic liver disease patients during the COVID-19 pandemic.
  • To emphasize the importance of SARS-CoV-2 vaccination for individuals with chronic liver disease and cirrhosis.

Main Methods:

  • Review of updated clinical management guidelines.
  • Analysis of the benefits of SARS-CoV-2 vaccination in the context of chronic liver disease.

Main Results:

  • COVID-19 can present with significant hepatic involvement.
  • Vaccination against SARS-CoV-2 is strongly recommended for patients with chronic liver disease and cirrhosis.
  • Vaccination is associated with reduced rates of COVID-19 infection, hospitalization, and mortality in this population.

Conclusions:

  • Patients with chronic liver disease, including liver transplant candidates and recipients, benefit significantly from SARS-CoV-2 vaccination.
  • Vaccination is a critical strategy to mitigate COVID-19-related risks in individuals with pre-existing liver conditions.

Keywords:
Abnormal liver biochemistriesAcute liver diseaseCOVID-19Chronic liver diseaseCirrhosisLiver transplantationSARS-CoV-2Vaccination

More Related Videos

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia09:12

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia

Published on: February 3, 2023

2.6K
Fluorescent Laparoscopic Central Hepatectomy for Liver Cancer Using Indocyanine Green Negative Staining03:23

Fluorescent Laparoscopic Central Hepatectomy for Liver Cancer Using Indocyanine Green Negative Staining

Published on: March 17, 2023

824

Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
862
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
514
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
165
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
122
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
112
Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
377