Rhodium-catalyzed selenylation and sulfenylation of quinoxalinones 'on water'
Ram Sunil Kumar Lalji1,2, Prince1, Mohit Gupta1,3
1Bio-Organic Research Laboratory, Department of Chemistry, University of Delhi Delhi 110007 India singhbk@chemistry.du.ac.in.
Abstract:
A rhodium-catalysed, regioselective synthetic methodology for selenylation and sulfenylation of 3-phenyl quinoxolinones has been developed through N-directed C-H activation in the presence of silver triflimide, and silver carbonate using dichalcogenides 'on water'. The methodology has been proven to be efficient, regioselective and green. Using this method, a range of selenylations and sulfenylations of the substrates has been carried out in good to excellent yields. Further, late-stage functionalisation produced potential anti-tumour, anti-fungal and anti-bacterial agents making these compounds potential drug candidates.
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