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Classification and Grading Systems in Gastric Adenocarcinomas.
Oana Iulia Crețu1, Alex Emilian Stepan2, Cristiana Eugenia Simionescu2
1PhD Student, Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania.
Current Health Sciences Journal
|February 23, 2023
Summary
This study analyzed gastric adenocarcinoma classification systems. The Lauren and WHO 2019 classifications showed strong concordance with grading systems, aiding diagnosis and treatment decisions.
Area of Science:
- Oncology
- Pathology
Background:
- Gastric adenocarcinomas present clinical challenges due to their incidence and behavior.
- Accurate classification and grading are crucial for effective patient management.
Purpose of the Study:
- To statistically analyze the efficacy and concordance of different classification and grading systems for gastric adenocarcinomas.
- To identify systems that improve diagnostic accuracy and assessment of tumor aggressiveness.
Main Methods:
- Statistical analysis of 112 gastric adenocarcinoma cases.
- Evaluation of various classification systems, including Lauren and WHO 2019.
- Comparison with two-tier and three-tier grading systems.
Main Results:
- A significant association was found between the Lauren classification and the WHO 2019 classification.
- Both classifications demonstrated significant concordance with the two-tier and three-tier grading systems.
- These findings support the practical utility of these systems in histopathological diagnosis.
Conclusions:
- The Lauren and WHO 2019 classification systems are effective for gastric adenocarcinomas.
- Concordance with grading systems aids in assessing tumor aggressiveness.
- These validated systems are valuable for guiding differentiated therapy.
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