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Scope and Consistency of Cancer Outcomes Reported in Randomized Trials in Kidney Transplant Recipients
Eric H Au1,2,3, Germaine Wong1,2,3, Allison Tong1,2
1Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Kidney International Reports
|February 23, 2023
Summary
Cancer outcomes are inconsistently reported in kidney transplant trials. Standardized definitions are needed to improve understanding of cancer in these patients.
Area of Science:
- Nephrology
- Oncology
- Clinical Trials Methodology
Background:
- Cancer is a significant concern for kidney transplant recipients.
- The reporting and definition of cancer outcomes in clinical trials for these patients lack evaluation.
Purpose of the Study:
- To assess the variability and scope of cancer outcome definitions and reporting in randomized controlled trials (RCTs) involving kidney transplant recipients.
Main Methods:
- A systematic search of ClinicalTrials.gov (February 2000 - July 2021) identified RCTs in adult kidney transplant recipients with cancer as a specified outcome.
- Data extracted included cancer definitions, types, measurement timepoints, and aggregation methods.
Main Results:
- Only 10% of kidney transplantation trials (84/819) reported cancer outcomes, mostly as secondary endpoints (86%).
- The term "malignancy" was most common (43%), often without specific diagnostic criteria.
- Post-transplant lymphoproliferative disorder (PTLD) and non-melanoma skin cancer were the most frequent types reported.
Conclusions:
- Cancer is infrequently and inconsistently reported in kidney transplant trials.
- Standardized definitions and reporting of cancer outcomes are crucial for better understanding cancer's impact post-transplantation.
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