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Comparing Strategies for Critical Congenital Heart Disease Newborn Screening
Pei-Chen Tsao1,2, Szu-Hui Chiang3, Yu-Shih Shiau3
1Division of Neonatology and Pediatric Critical Care, Department of Pediatrics.
Pediatrics
|February 23, 2023
Summary
Taipei
Area of Science:
- Neonatal screening
- Pediatric cardiology
- Public health
Background:
- An extended newborn critical congenital heart disease (CCHD) screening program using oximetry was implemented in Taipei, Taiwan in April 2014.
- This program aimed to investigate the test accuracy and efficiency of the screening protocol.
Purpose of the Study:
- To evaluate the accuracy and efficiency of an extended newborn critical congenital heart disease (CCHD) screening program.
- To assess the effectiveness of the Taipei CCHD screening protocol in a community setting.
Main Methods:
- Analysis of data from 30 birthing facilities in Taipei, covering 87.9% of live births.
- Definition of positive screening: oxygen saturation <95% or preductal-postductal difference >3%.
- Retrospective estimation of outcomes based on different CCHD screening protocols.
Main Results:
- Nearly 99% of eligible infants were screened, with a 0.17% referral rate.
- 42 CCHD cases were detected, with 97.6% diagnosed within 72 hours.
- False positive rate was 0.12%, and false negative rate was 0.04%.
Conclusions:
- The Taipei protocol demonstrated an efficient and effective screening referral system.
- Advocated for an updated protocol (AAP/Spanish recommendation) for optimal efficiency.
- The updated protocol is suitable for nationwide implementation in Taiwan and similar healthcare systems.
