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Updated: Aug 9, 2025

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
Published on: February 28, 2013
[Monogenic diabetes : a pioneer in precision medicine management]
Fanny Iafrate-Luterbacher1, Mirjam Dirlewanger1, Michael Hauschild2
1Unité d'endocrinologie et diabétologie pédiatriques, Service de développement et croissance, Département de pédiatrie, gynécologie et obstétriques, Hôpitaux universitaires de Genève, 1211 Genève 14.
Abstract:
Diabetes mellitus in children is subdivided into several categories depending on the underlying pathological mechanism. Type 1 diabetes is due to the autoimmune destruction of pancreatic beta-cells, type 2 diabetes to progressive impairment in insulin secretion or insulin sensitivity, and monogenic diabetes due to genetic abnormalities, impairing insulin secretion. In monogenic diabetes, genetic defects result in pancreatic or beta-cell defects (abnormal function or destruction), resulting in neonatal or MODY (Maturity-Onset Diabetes of the Young) diabetes, depending on the age of onset. The identification of monogenic diabetes is crucial as it allows the initiation of targeted and personalized treatment.
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