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Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

259

[Obesity in infancy: new precision treatment]

Inge Ruiz1, Thérèse Bouthors1, Sylvie Borloz1

  • 1Unité d'endocrinologie, diabétologie et obésité pédiatrique, Service de pédiatrie, Département femme-mère-enfant, Centre hospitalier universitaire vaudois, 1011 Lausanne.

Revue Medicale Suisse
|February 23, 2023
PubMed

Insights

Childhood obesity affects 4% of Swiss youth and requires early intervention to prevent adult complications. Genetic testing can identify specific causes, enabling targeted treatments like leptin or setmelanotide for monogenic obesity.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Genetics

Context:

  • Childhood obesity is a chronic disease with significant short- and long-term health consequences.
  • Approximately 4% of children and adolescents in Switzerland are affected by obesity.
  • Early diagnosis and intervention are crucial to prevent the persistence of obesity into adulthood.

Purpose:

  • To highlight the importance of prompt diagnosis and multicomponent lifestyle interventions for childhood obesity.
  • To emphasize the role of growth and BMI charts in diagnosing obesity and its etiology.
  • To discuss the suspicion and molecular diagnosis of monogenic obesity and its targeted therapies.

Summary:

  • Growth and BMI charts are essential for diagnosing obesity and identifying its cause in children.
  • Severe, early-onset obesity with hyperphagia suggests monogenic obesity, requiring molecular diagnosis.
  • Specific genetic defects (LEP, LEPR, POMC, PCSK1) allow for targeted treatments such as leptin or setmelanotide.

Impact:

  • Early identification and intervention can mitigate the long-term health impacts of childhood obesity.
  • Molecular diagnosis of monogenic obesity opens avenues for personalized and effective therapeutic strategies.
  • Understanding the genetic basis of obesity can lead to improved patient outcomes and management protocols.

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