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Related Experiment Video

Updated: Aug 9, 2025

Generation of Functional Endodermal Hepatic Organoids
08:45

Generation of Functional Endodermal Hepatic Organoids

Published on: May 2, 2025

401

Human liver organoids: From generation to applications.

Marta B Afonso1, Vanda Marques1, Saskia W C van Mil2

  • 1Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal.

Hepatology (Baltimore, Md.)
|February 23, 2023
PubMed
Summary

Mini human livers in a dish, or liver organoids, are revolutionizing hepatology. These self-organizing stem cell models mimic native livers, advancing disease modeling and drug testing.

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Area of Science:

  • Hepatology and stem cell biology.
  • Development of in vitro human liver models.

Background:

  • Human liver organoids, self-organizing stem cell derivatives, closely mimic native liver structure and function.
  • These models can be generated from various cell sources, including liver tissue and pluripotent stem cells.

Purpose of the Study:

  • To review strategies for generating and utilizing liver organoids for human liver disease modeling.
  • To discuss the application of liver organoids in drug development, personalized medicine, and bioengineering.

Main Methods:

  • Review of current literature on liver organoid generation and application.
  • Analysis of self-organization principles in stem cell-derived organoids.

Main Results:

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Last Updated: Aug 9, 2025

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  • Liver organoids offer a revolutionary approach to studying human hepatology.
  • They present significant potential for modeling liver diseases and improving drug efficacy testing.

    • Conclusions:

    • Liver organoids are poised to overcome previous challenges in human liver research.
    • Their application holds promise for advancing personalized medicine and therapeutic strategies in liver disease.