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Inter-organ Crosstalk and the Effect on the Aging Process in Obesity
Ferah Armutcu1,2, Oguz Aslan Ozen3
1Department of Biochemistry, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
Current Aging Science
|February 23, 2023
Summary
Obesity and aging accelerate tissue dysfunction and inflammation, driven by changes in adipose tissue and interorgan communication. Understanding these links aids in diagnosing and treating age-related metabolic diseases.
Area of Science:
- Gerontology
- Metabolic disease research
- Endocrinology
Background:
- Aging involves functional decline and chronic inflammation, increasing disease risk.
- Obesity and aging share links to metabolic diseases and increased senescent cells.
- Adipose tissue, an endocrine organ, secretes adipokines crucial for metabolic homeostasis; dysfunction contributes to disease.
Conclusions:
- Adipose tissue dysfunction and altered interorgan communication are central to aging and obesity-related diseases.
- Targeting these pathways may offer therapeutic strategies for age-related metabolic dysfunction.
- Improved understanding of interorgan communication is vital for early diagnosis and effective management.
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