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Updated: Aug 9, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Lanthanide-catalyzed deamidative cyclization of secondary amides and ynones through tandem C-H and C-N activation
Junxi Zhang1, Yitu Wang1, Xigeng Zhou1,2
1Department of Chemistry, Fudan University, Shanghai, 200438, China. xgzhou@fudan.edu.cn.
Abstract:
The tandem inert α-C-H and C-N bond activation of amides represents a highly valuable but challenging transformation in organic synthesis. Herein, a simple rare earth metal amido complex has been shown to catalyse unprecedented cyclization of amides with ynones to form trisubstituted 2-pyrones. This protocol significantly enables the selective merger of inert α-C-H and C-N bond activations of amides and indicates a particular role of rare earth catalysts in enhancing the selectivity for the α-C-H bond of amides in the presence of N-H bonds.
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