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Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
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Implications of altered sirtuins in metabolic regulation and oral cancer

Xu Quan1, Ying Xin2,3, He-Ling Wang4

  • 1Department of Stomatology, Shanghai General Hospital, Shanghai, China.

Peerj
|February 23, 2023
PubMed

Insights

Sirtuins (SIRTs 1-7) are enzymes regulating metabolism, aging, and cancer. This review details their roles in metabolic regulation and oral carcinogenesis, highlighting potential therapeutic targets.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Sirtuins (SIRTs 1-7) are histone deacetylase enzymes involved in diverse cellular processes.
  • They regulate metabolism, aging, longevity, and are implicated in various pathological conditions.

Conclusions:

  • Sirtuins are key regulators of cellular functions and metabolic phenotypes.
  • Targeting sirtuins offers potential therapeutic strategies for oral malignancies.
  • Further research into sirtuin mechanisms can advance cancer treatment.
Keywords:
Metabolic regulationOral cancerSirtuin

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