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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
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Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Factors Affecting the Risk of Infection01:26

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
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Related Experiment Video

Updated: Aug 9, 2025

A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
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Is Increased BMI a Risk Factor for Developing Severe Clostridioides Difficile Infection? A Retrospective Study.

Tulika Chatterjee1, Saurabh Bansal2, Asif Abuzar3

  • 1Assistant Professor of Clinical Medicine, 530 NE Glen Oak Ave, University of Illinois College of Medicine at Peoria, Peoria, IL, 61637, USA.

Journal of Community Hospital Internal Medicine Perspectives
|February 23, 2023
PubMed
Summary

Obesity does not appear to influence the severity of Clostridioides difficile infection (CDI). This study found no significant association between body mass index (BMI) and severe CDI outcomes.

Keywords:
Clostridioides difficileClostridioides difficile diarrheaClostridium difficileClostridium difficile diarrheaClostridium difficile infectionDysbiosisHost-pathogen interactionsObesityRetrospective studies

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A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Obesity is linked to an increase in specific bacterial phyla, potentially facilitating Clostridioides difficile colonization.
  • Higher body mass index (BMI) is hypothesized to increase susceptibility to severe Clostridioides difficile infection (CDI).

Purpose of the Study:

  • To investigate the association between body mass index (BMI) and the severity of Clostridioides difficile infection (CDI).

Main Methods:

  • A retrospective chart review was conducted on 219 patients.
  • Severe CDI was defined by elevated white blood cell count or serum creatinine levels.
  • Covariates included age, gender, albumin, ICU admission, recent antibiotic use, diabetes, and hypertension; specific conditions were excluded.

Main Results:

  • Obesity, overweight, or underweight status did not significantly influence the risk of severe CDI compared to normal weight.
  • Male gender was associated with a higher likelihood of severe CDI (OR = 1.76, p = 0.0395).
  • Lower albumin levels were significantly associated with increased odds of severe CDI (OR = 0.41, p < 0.0001).

Conclusions:

  • Body mass index (BMI) does not appear to be a significant factor in determining the severity of Clostridioides difficile infection (CDI).
  • Male gender and lower albumin levels are associated with increased severity of CDI.